Association of iron status with all-cause and cause-specific mortality in individuals with diabetes
Authors' conclusion
Moderate levels of serum ferritin (300-500 ng/mL), Tsat (25 %-32 %) and a lower concentration of sTfR (< 4 mg/L) identified adults with diabetes with lower all-cause mortality risk, adding novel modifiers to diabetes management.
Study context
- Population
- Adults with diabetes, NHANES 1999–2018; 2080 with ferritin, 1974 with transferrin saturation (Tsat) and 1106 with soluble transferrin receptor (sTfR) data
- Exposure
- Categories of iron indices and mortality
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Through December 31, 2019
Methodological detailsNHANES 1999-2018, linked to National Death Index, Cox proportional hazards models
- NHANES 1999-2018
- Linked to National Death Index
- Cox proportional hazards models
Main finding
As reported in the abstract
All-cause mortality
J-shaped association for serum ferritin
Pnonlinearity < 0.01
U-shaped association for Tsat
Pnonlinearity < 0.01
Linear association for sTfR
Plinearity < 0.01
Observational data: associations, not effects.
Original publication
Association of iron status with all-cause and cause-specific mortality in individuals with diabetes. Diabetes Res Clin Pract. Published 15 December 2023. doi:10.
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