Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration
Authors' conclusion
Type 2 diabetes is associated with an increased pro-inflammatory potential of cytotoxic blood lymphocytes correlating with age and diabetes duration. Further research is necessary to explore potential benefits of diabetes medications in reverting this effect.
Study context
- Population
- Patients with T2D and control subjects
- Participants
- 49 vs 30
- Exposure
- T2D vs controls
- T2Dn = 49
- Controlsn = 30reference
- Outcome
- Phenotype, proliferation and cytokine production of cytotoxic lymphocytes
Methodological detailsmultiparametric flow cytometry
- Multiparametric flow cytometry
Main finding
As reported in the abstract
- T2D did not impact the phenotype or proliferation of the investigated cells
- Significantly increased TNF-α production by CD8+ T cells in T2D vs controls
- Significantly increased Granzyme B production by NK cells and γδ T cells in T2D vs controls
- Hyperresponsiveness did not correlate with glycaemia or BMI; associated with older age and longer diabetes duration
Observational data: associations, not effects.
Original publication
Inflammageing mediated by cytotoxic lymphocytes is associated with diabetes duration. Diabetes Res Clin Pract. Published 15 December 2023. doi:10.
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