Association of glycemic control with arterial stiffness and hemodynamic function in type 2 diabetes mellitus
Authors' conclusion
Poor glycemic control in T2DM exacerbates arterial stiffening, hemodynamic disturbance, and endothelial dysfunction. Multidimensional vascular ultrasound enables early detection of subclinical vascular damage
Study context
- Population
- Patients with T2D and healthy controls undergoing carotid US and flow-mediated dilation (FMD)
- Participants
- 228 vs 52
- Exposure
- T2D stratified by HbA1c levels vs healthy controls
- T2DMn = 228
- Healthy controlsn = 52reference
- Outcome
- Association of HbA1c with arterial stiffness and hemodynamic function (multiple linear regression, adjusted for potential confounders)
Main finding
As reported in the abstract
- Hardness coefficient (HC) independently positively associated with HbA1c, B (P < 0.05)
- 0.286
- Pulse wave velocity (PWV) independently positively associated with HbA1c, B (P < 0.05)
- 0.243
- Maximal wall shear stress (WSSmax) independently negatively associated with HbA1c, B (P < 0.05)
- −0.072
- Mean wall shear stress (WSSmean) independently negatively associated with HbA1c, B (P < 0.05)
- −0.051
- FMD independently negatively associated with HbA1c, B (P < 0.05)
- −0.277
Observational data: associations, not effects.
Further findings
Trends across HbA1c levels
- Intima-media thickness, HC and PWV showed upward trend as HbA1c increased (P for trend < 0.05)
- Displacement, end-diastolic velocity, WSSmax, WSSmean and FMD showed downward trend as HbA1c increased (P for trend < 0.05)
Original publication
Association of glycemic control with arterial stiffness and hemodynamic function in type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 8 June 2026. doi:10.
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