Impact of weight loss and weight gain trajectories on body composition in a population at high risk of type 2 diabetes: A prospective cohort analysis
Authors' conclusion
Weight cycling may be associated with a progressive loss in FFM and/or gain in FM in those with overweight and obesity at-risk of type 2 diabetes.
Study context
- Population
- Primary care adults at high risk of T2D, recruited 2009/10; mean age 63.6 years, BMI 32.0 kg/m², 35.4% women1,163 observations
- Participants
- 622 adults
- Exposure
- Weight change trajectories over 24 months
- Outcome
- Change in fat mass (FM) and fat-free mass (FFM) by bioelectrical impedance
- Follow-up
- 24 months
Methodological detailssecondary analysis of the Walking Away from Type 2 Diabetes trial cohort, generalized estimating equations, up to two 24-month observation periods per participant
- Secondary analysis of the Walking Away from Type 2 Diabetes trial cohort
- Generalized estimating equations
- Up to two 24-month observation periods per participant
Main finding
As reported in the abstract
FM and FFM change by weight trajectory
- Weight maintained: share of observations, no change to fat mass (FM) or fat-free mass (FFM)
- 69.2%
- Loss then regain: share of observations
- 4.6%
- Loss then regain: FM regained to baseline; FFM lost (adjusted)
- 1.50 (0.66, 2.35) kg
- Gain then loss: share of observations
- 5.5%
- Gain then loss: net FM gain (no change to FFM)
- 1.70 (0.27, 3.12) kg
Observational data: associations, not effects.
Original publication
Impact of weight loss and weight gain trajectories on body composition in a population at high risk of type 2 diabetes: A prospective cohort analysis. Diabetes Obes Metab. Published 14 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →