Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study
Authors' conclusion
IR is associated with radiographic lung abnormalities and incident lung disease. Deeper phenotyping is necessary to define mechanisms of IR-associated lung injury.
Study context
- Population
- Framingham Offspring Study participants without baseline lung disease; mean age 51.5 years, BMI 26.7 kg/m²
- Participants
- 875 participants
- Exposure
- Per 1 SD increase in log z score
- Outcome
- Radiographic outcomes on whole-lung CT (emphysema, ILAs, quantitative airway features) and examiner-identified incident lung disease
Methodological detailslongitudinal, adjusted for demographics, BMI and lifetime smoking, Time-weighted average HOMA-IR from repeated fasting insulin and glucose over an average 13.6 years
- Longitudinal
- Adjusted for demographics, BMI and lifetime smoking
- Time-weighted average HOMA-IR from repeated fasting insulin and glucose over an average 13.6 years
Main finding
As reported in the abstract
Radiographic lung abnormalities per 1 SD increase in log(HOMA-IR) z score
Qualitative emphysema, OR
1.33
95% CI 1.04–1.70
Interstitial lung abnormalities (ILAs), OR
1.35
95% CI 1.05–1.74
Observational data: associations, not effects.
Further findings
Incident lung disease
- Positive association of HOMA-IR with incident lung disease
HOMA-IR stability · average 13.6 years
- HOMA-IR temporally unstable; within-person SD approximately two-thirds of between-person SD
Original publication
Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study. Diabetes Care. Published 21 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →