Burden and Excess Risk of Adverse Outcomes in Patients With Type 1 Diabetes Using KDIGO Classification: A National Cohort Study
Authors' conclusion
A progressively increasing burden of all studied adverse outcomes was observed with advancing KDIGO categories. Even individuals with preserved eGFR and normoalbuminuria (G2A1), conventionally perceived as non-CKD, had an excess risk for all outcomes.
Study context
- Population
- Individuals with T1D, Swedish National Diabetes Register39,067 included
- Participants
- 40,199 individuals
- Exposure
- KDIGO estimated glomerular filtration rate (eGFR) and albuminuria categories vs low-risk reference categories
- Outcome
- Prevalence of CKD (eGFR <60 mL/min/1.73 m² and/or albuminuria) at baseline
- Follow-up
- Baseline
Methodological detailsnational, observational, Cox regression with three different reference categories
- National
- Observational
- Cox regression with three different reference categories
Main finding
As reported in the abstract
Chronic kidney disease (CKD) prevalence
18.5%
Observational data: associations, not effects.
Original publication
Burden and Excess Risk of Adverse Outcomes in Patients With Type 1 Diabetes Using KDIGO Classification: A National Cohort Study. Diabetes Care. Published 20 November 2024. doi:10.
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