Association of Healthy Lifestyle Factors and Obesity-Related Diseases in Adults in the UK
Authors' conclusion
In this large cohort study, adherence to a healthy lifestyle was associated with reduced risk of a wide range of obesity-related diseases, but this association was modest in adults with obesity.
Study context
- Population
- UK Biobank participants aged 40 to 73 years, free of major obesity-attributable disease at baseline, enrolled 2006 to 2010107,041 (24.4%) with obesity
- Participants
- 438,583 participants
- Exposure
- Healthy lifestyle score in adults with obesity; obesity vs normal weight
- Outcome
- Risk of obesity-related diseases according to healthy lifestyle score in adults with obesity vs normal weight (multivariable Cox models, Bonferroni correction)
Methodological detailsmultivariable Cox proportional hazards models, Bonferroni correction for multiple testing, Data analysis performed between December 1, 2021, and October 31, 2022
- Multivariable Cox proportional hazards models
- Bonferroni correction for multiple testing
- Data analysis performed between December 1, 2021, and October 31, 2022
Main finding
As reported in the abstract
Obesity-related diseases, obesity with 4 vs 0 healthy lifestyle factors
Estimate (95% CI)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (hypertension) 0.84(0.78–0.90)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (ischemic heart disease) 0.72(0.65–0.80)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (arrhythmias) 0.71(0.61–0.81)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (HF) 0.65(0.53–0.80)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (arteriosclerosis) 0.19(0.07–0.56)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (kidney failure) 0.73(0.63–0.85)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (gout) 0.51(0.38–0.69)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (sleep disorders) 0.68(0.56–0.83)
OBESITY, 4 HEALTHY LIFESTYLE FACTORSvs OBESITY, 0 HEALTHY LIFESTYLE FACTORS
HR (mood disorders) 0.66(0.56–0.78)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Obesity vs normal weight, adults with obesity and 4 healthy lifestyle factorsOBESITY, 4 HEALTHY LIFESTYLE FACTORSvs NORMAL WEIGHTLowest of the range | aHR (arrhythmias) 1.41 (95% CI 1.27–1.56) | |
| Obesity vs normal weight, adults with obesity and 4 healthy lifestyle factorsOBESITY, 4 HEALTHY LIFESTYLE FACTORSvs NORMAL WEIGHTHighest of the range | aHR (diabetes) 7.16 (95% CI 6.36–8.05) | |
| 0.10.31310Ratio (log scale) |
Obesity vs normal weight, adults with obesity and 4 healthy lifestyle factors
- Obesity at higher risk of several outcomes vs normal weight, irrespective of lifestyle score
Original publication
Association of Healthy Lifestyle Factors and Obesity-Related Diseases in Adults in the UK. JAMA Netw Open. Published 1 May 2023. doi:10.
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