Association of genetic variation with age at diagnosis in type 1 diabetes
Authors' conclusion
We identified rs76730244 in the MHC region for age at diagnosis of type 1 diabetes, which was independent of the HLA-DR3/DR4 genotype categories. We also confirmed 6 previously identified SNPs and showed that 11 non-HLA loci for type 1 diabetes risk are associated with age at diagnosis.
Study context
- Population
- Individuals with T1D from eight cohorts
- Participants
- 5,910 individuals8 cohorts
- Outcome
- Age at diagnosis of T1D (SNP associations)
Methodological details8 cohorts, 3 models
- 8 cohorts
- 3 models
Pooled result
As reported in the abstract
SNP associations with age at diagnosis
- Model 1 (no covariates): genome-wide significant major histocompatibility complex (MHC) locus rs2856721
- p=3.3×10-11
- rs2856721 effect attenuated in model 2 (adjusted for DR3/DR4 genotypes)
- p=0.03
- Model 2 (adjusted for DR3/DR4 genotypes): MHC locus rs76730244
- p=4.9×10-9
Further pooled results
Replication of previously identified loci (model 1)
- Previously identified single-nucleotide polymorphisms (SNPs) for age at diagnosis confirmed
- 6 of 14
- Non-HLA T1D risk loci associated with age at diagnosis
- 11 of 78
Original publication
Association of genetic variation with age at diagnosis in type 1 diabetes. BMJ Open Diabetes Res Care. Published 16 January 2026. doi:10.
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