Trans‐ancestry meta‐analysis of genome‐wide association study identifies eight novel genetic loci in type 1 diabetes: A multi‐population study
Authors' conclusion
These findings suggest that, for T1D, increasing ancestral diversity in genetic studies helps identify core genes and provides new insights into pathogenesis.
Study context
- Population
- European and Asian individuals with T1D and controls
- Participants
- 680,539 vs 133,251
- Comparison
- European vs Asian
- Europeann = 680,539
- Asiann = 133,251
- Outcome
- Genetic associations with T1D
Methodological detailsmulti-population, fine-mapping, Summary-data-based Mendelian randomization
- Multi-population
- Fine-mapping
- Summary-data-based Mendelian randomization
Pooled result
As reported in the abstract
T1D-associated loci
T1D-associated loci identified
27
Potentially novel loci (near CDKAL1, NRSN1, FAM65B, LRRC16A, TULP1, SLC17A3, LRIG2, C6orf1)
8
Further pooled results
Fine-mapping: putative causal variants (posterior probability >0.95)
- Putative causal variants
- 7
- rs9366622 (near LRRC16A; lead SNP of novel locus), PP
- 0.976
- rs1165190 (near SLC17A3; lead SNP of novel locus), PP
- 0.996
SMR analysis
- Putative risk gene U91328.19 at novel locus SLC17A3-rs1165190, expression causally associated with T1D
Original publication
Trans‐ancestry meta‐analysis of genome‐wide association study identifies eight novel genetic loci in type 1 diabetes: A multi‐population study. Diabet Med. Published 13 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →