Lipids & metabolic liver disease
Association of five diet scores with severe non-alcoholic fatty liver disease (NAFLD) incidence: A prospective study from UK Biobank
Authors' conclusion
MEDAS-14, RFS and HDI scores were the strongest diet score predictors of severe NAFLD. A healthy diet might protect against NAFLD development irrespective of the specific approach used to assess diet. However, following these score recommendations could represent optimal dietary approaches to mitigate NAFLD risk.
Study context
- Population
- UK Biobank participants; diet assessed by Mediterranean Diet Adherence Screener (MEDAS-14), Recommended Food Score (RFS), Healthy Diet Indicator (HDI), Mediterranean Diet Score and Mediterranean-DASH Intervention for Neurodegenerative Delay score1,370 severe NAFLD cases
- Participants
- 162,999 participants
- Exposure
- Standardized diet score quartiles for five diet scores
- Outcome
- Severe NAFLD incidence
- Follow-up
- Median 10.2 years
Methodological detailsUK Biobank, Cox proportional hazard models, fully adjusted
- UK Biobank
- Cox proportional hazard models, fully adjusted
Main finding
As reported in the abstract
Severe incident NAFLD, by standardized diet-score quartile (fully adjusted Cox models)
Hazard ratio (95% CI)
Quartile 4vs Quartile 1MEDAS-14 score
0.76(0.62–0.94)
Quartile 4vs Quartile 1RFS score
0.82(0.69–0.96)
Quartile 2vs Quartile 1HDI score
0.80(0.70–0.91)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of five diet scores with severe NAFLD incidence: A prospective study from UK Biobank. Diabetes Obes Metab. Published 23 November 2023. doi:10.
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