Association of COVID-19 Infection With Incident Diabetes
An erratum to this article was published (JAMA Netw Open, 1 May 2023 ↗)
Main finding · Incident diabetesResult — go to the resultHazard ratio 1.17 95% CI 1.06–1.28Authors' conclusion
In this cohort study, SARS-CoV-2 infection was associated with a higher risk of diabetes and may have contributed to a 3% to 5% excess burden of diabetes at a population level.
Study context
- Population
- Individuals tested for SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT-PCR), British Columbia COVID-19 Cohort, Canada, Jan 2020–Dec 2021; median age 32 years, 51.2% femalematched cohort
- Participants
- 629,935 individuals
- Exposure
- SARS-CoV-2 positive vs negative
- Exposedn = 125,987
- Unexposedn = 503,948reference
- Outcome
- Incident diabetes (insulin dependent or not) identified >30 days after SARS-CoV-2 test specimen collection, by validated algorithm
- Follow-up
- Median 257 (IQR 102-356) days
Methodological detailsmatched 1:4 on sex, age and RT-PCR collection date
- Matched 1:4 on sex, age and RT-PCR collection date
Main finding
Incident diabetes · median (IQR) follow-up 257 (102-356) days
Hazard ratio
1.17
95% CI 1.06–1.28
Events by group
Exposedvs Unexposed
HR 1.17 (95% CI 1.06–1.28)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Incident diabetes among malesMales | aHR 1.22 (95% CI 1.06–1.40) | |
| Incident diabetes by severity: ICU admissionvs no COVID-19 | HR 3.29 (95% CI 1.98–5.48) | |
| Incident diabetes by severity: hospital admissionvs no COVID-19 | HR 2.42 (95% CI 1.87–3.15) | |
| 0.20.5125Ratio (log scale) |
Fraction of incident diabetes attributable to SARS-CoV-2 infection
- Overall
- 3.41% (95% CI, 1.20%-5.61%)
- Males
- 4.75% (95% CI, 1.30%-8.20%)
Original publication
Association of COVID-19 Infection With Incident Diabetes. JAMA Netw Open. Published 3 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →