Long-term Risk of Prediabetes and Type 2 Diabetes Following SARS-CoV-2 Infection: A Nationwide Cohort Study
Authors' conclusion
SARS-CoV-2 infection is associated with a significantly increased risk of developing prediabetes and type 2 diabetes, with the highest incidence observed during the acute postinfection phase and persistent elevation in risk extending up to 5 years.
Study context
- Population
- Adults tested for COVID-19 between January 1, 2020, and December 31, 2020, without prior SARS-CoV-2 infection, prediabetes or T2Dmedian follow-up 2.6 years
- Participants
- 5,084,889 adults
- Exposure
- SARS-CoV-2 infection vs negative COVID-19 test
- Positiven = 599,744
- Negativen = 4,485,145reference
- Outcome
- Incidence of prediabetes and T2D
- Follow-up
- 5-year period
Methodological detailsnationwide, propensity score matching
- Nationwide
- Propensity score matching
Main finding
As reported in the abstract
Prediabetes, HR (95% CI), confirmed SARS-CoV-2 infection vs uninfected
1.23
1.21–1.25
T2D, HR (95% CI), confirmed SARS-CoV-2 infection vs uninfected
1.40
1.37–1.43
Observational data: associations, not effects.
Further findings
Incident prediabetes and T2D within first month after infection, SARS-CoV-2 infection vs uninfected · first month following infection
- Prediabetes, HR
- 1.87 (1.75-1.98) (95% CI)
- T2D, HR
- 1.87 (1.79-1.96) (95% CI)
- Risk most pronounced in first month
Incident prediabetes and T2D over subsequent 5 years, SARS-CoV-2 infection vs uninfected
- Prediabetes, HR
- 1.23 (1.20-1.27) (95% CI)
- T2D, HR
- 1.48 (1.43-1.53) (95% CI)
- Attenuated but remained significantly elevated
Original publication
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