Association of central obesity with retinal neurodegeneration: Cross‐sectional and longitudinal evidence from two countries
Main finding · GCIPLT (cross-sectional, UK Biobank)Result — go to the resultβ −0.33 μm 95% CI −0.61 to −0.04Authors' conclusion
Even with normal weight, central obesity was associated with accelerated GCIPLT thinning cross-sectionally and longitudinally.
Study context
- Population
- UK Biobank (n=22,827; mean age 55.06 [SD 8.27] years, 53.2% women) and Chinese Ocular Imaging Project (n=2082; mean age 63.02 [SD 8.35] years, 61.9% women)22,827 UK Biobank
- Exposure
- Obesity phenotypes by BMI and waist to hip ratio (WHR) vs normal BMI/normal WHR
- Outcome
- Retinal ganglion cell-inner plexiform layer thickness (GCIPLT) by optical coherence tomography (OCT)
Methodological detailstwo cohorts (UK Biobank cross-sectional; Chinese Ocular Imaging Project (COIP) longitudinal), multivariable linear regression
- Two cohorts (UK Biobank cross-sectional; COIP longitudinal)
- Multivariable linear regression
Main finding
GCIPLT (cross-sectional, UK Biobank)
β
−0.33 μm
95% CI −0.61 to −0.04
P = 0.045
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | β (μm/y) (95% CI) | P value |
|---|---|---|
| GCIPLT thinning (longitudinal, COIP) · 2-year follow-upNormal BMI/high WHR vs Normal BMI/normal WHR · accelerated thinning with normal BMI/high WHR | −0.28 (−0.45 to −0.10) | P = 0.02 |
Ganglion cell-inner plexiform layer thickness (GCIPLT) thinning (longitudinal, COIP) · 2-year follow-up
- Obesity/normal WHR not associated with accelerated GCIPLT thinning
Original publication
Association of central obesity with retinal neurodegeneration: Cross‐sectional and longitudinal evidence from two countries. Obesity (Silver Spring). Published 6 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →