Association of body weight change with all-cause and cause-specific mortality: A nationwide population-based study
Authors' conclusion
In a middle-aged and elderly population, weight gain or loss of more than 3% during a 2-year interval was related to an elevated risk of all-cause and cause-specific mortality.
Study context
- Population
- Adults aged 40 to 80 with health checkups twice within a 2-year interval, January 2009–December 2012
- Participants
- 645,260 adults
- Exposure
- Short-term weight change categories vs stable weight
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- 8.4 years
Methodological detailsnationwide, population-based
- Nationwide
- Population-based
Main finding
As reported in the abstract
All-cause mortality
Hazard ratio (95% CI)
Severe weight loss
2.05(1.93–2.16)
Moderate weight loss
1.21(1.16–1.25)
Moderate weight gain
1.12(1.08–1.17)
Severe weight gain
1.60(1.49–1.70)
Observational data: associations, not effects.
Further findings
Cause-specific mortality
- U-shaped association also seen between weight change and cause-specific mortality
Weight regain within weight loss group · after two years
- Those who regained weight after two years had a reduced mortality risk
Original publication
Association of body weight change with all-cause and cause-specific mortality: A nationwide population-based study. Diabetes Res Clin Pract. Published 7 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →