Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study
Authors' conclusion
Among individuals with prediabetes or diabetes in DPPOS, overweight or obesity was associated with slower decline in verbal learning and memory compared with those with normal BMI.
Study context
- Population
- Diabetes Prevention Program Outcomes Study (DPPOS) participants with diabetes or prediabetes; mean ± SD age 51.1 ± 10.0 years, 67.7% female; 31% overweight and 60% obesity at Y8
- Participants
- 2,285 completed cognitive assessments
- Exposure
- Overweight or obesity vs normal BMI at DPPOS Y8
- Outcome
- Cognitive test scores (B-SEVLT, Digit Symbol Substitution test (DSST)) related to BMI at Y8
- Follow-up
- Y8, Y10 and Y15
Methodological detailssecondary analysis of the Diabetes Prevention Program Outcomes Study, linear mixed models accounting for repeated measures
- Secondary analysis of the Diabetes Prevention Program Outcomes Study
- Linear mixed models accounting for repeated measures
Main finding
As reported in the abstract
B-SEVLT immediate and delayed recall decline · Y8 to Y15
- Overweight or obesity at Y8: slower decline in Brief Spanish English Verbal Learning Test (B-SEVLT) immediate and delayed recall vs normal BMI
Observational data: associations, not effects.
Further findings
3MS score · Y15
- 3MS performance higher with overweight or obesity vs normal BMI
Original publication
Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study. Obesity (Silver Spring). Published 28 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →