Development and Internal Validation of the Multiethnic Type 2 Diabetes Outcomes Model for the U.S. (DOMUS)
Authors' conclusion
The resulting Diabetes Outcome Model of the U.S. (DOMUS) is a major step forward in understanding diabetes progression and the role of social determinants of health. This model can be used by scientists, policymakers, and health system managers to better understand how choices can affect population health and health disparities, including the broad diversity of U.S. races and ethnicities. Moreover, this model can be used to realize longer-term comparative effectiveness in cost-effectiveness analyses for diabetes management in the future.
Study context
- Population
- Adults (≥18 years) with newly diagnosed T2D, Kaiser Permanente Northern California, 2005–2016; followed ≥1 year, up to 12 yearsincidence cohort
- Participants
- 129,000 adults
- Outcome
- Model of 17 diabetes-related outcomes:
- Micro- and macrovascular disease
- AF
- Depression
- Dementia
- Biomarkers
- Mortality
Methodological detailsincidence cohort, random split: 50% estimation, 25% calibration, 25% validation
- Incidence cohort
- Random split: 50% estimation, 25% calibration, 25% validation
Performance
As reported in the abstract
Agreement of simulated with empirical data
- Empirical and simulated data were similar for events and biomarkers, but some factors required calibration
- After calibration, closely aligned with empirical estimates
Original publication
Development and Internal Validation of the Multiethnic Type 2 Diabetes Outcomes Model for the U.S. (DOMUS). Diabetes Care. Published 25 September 2025. doi:10.
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