Association of Blood Pressure With Cardio-Renal Events and Mortality in Type 2 DM: A National Health Insurance Database
Authors' conclusion
In patients with T2DM, the optimal cutoff value of BP associated with a lower incidence of MACE and mortality may be 120-129 mmHg for SBP and 75-79 mmHg for DBP. However, lower SBP may be helpful for T2DM patients with a high risk of renal disease.
Study context
- Population
- Korean individuals with T2DM who underwent regular health checks in 2007, Korean National Health Insurance System databaseof 1,800,073 extracted
- Participants
- 326,593 individuals
- Exposure
- Blood pressure (BP) categories vs systolic blood pressure (SBP) 120-129 mmHg and diastolic blood pressure (DBP) 75-79 mmHg
- Outcome
- Hazard ratios (HRs) of cardio-renal events and all-cause mortality according to BP categories
Methodological detailsnational health insurance database
- National health insurance database
Main finding
As reported in the abstract
MACE, all-cause mortality and renal events by BP category
- Vs SBP 120-129 mmHg and DBP 75-79 mmHg, SBP ≥130 mmHg and DBP ≥80 mmHg associated with increased HR of MACE
- SBP 120-129 mmHg and DBP 75-79 mmHg associated with lowest HR of all-cause mortality
- Both lower BP (SBP/DBP <120/70 mm) and higher BP (SBP/DBP ≥130/80 mmHg) associated with increased HR of all-cause mortality
- Contrary to MACE, the lower the SBP, the lower the HR of renal events
Observational data: associations, not effects.
Original publication
Association of Blood Pressure With Cardio-Renal Events and Mortality in Type 2 DM: A National Health Insurance Database. J Clin Endocrinol Metab. Published 11 July 2023. doi:10.
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