Efficacy of DPP ‐4 Inhibitors on Seated and Ambulatory Blood Pressure in Type 2 Diabetes Mellitus
Pooled result · Seated SBPResult — go to the resultDifference −1.69 mmHg 95% CI −2.78 to −0.61Authors' conclusion
DPP-4i might produce a small reduction in seated SBP compared with placebo, but the magnitude was modest and the clinical relevance for individual patients was uncertain. Evidence for DBP and ABP effects was inconclusive.
Study context
- Population
- RCTs in T2D reporting systolic BP (SBP), diastolic BP (DBP) or ambulatory blood pressure (BP)79 studies
- Comparison
- DPP-4i vs placebo
- Outcome
- Seated SBP
Methodological detailsplacebo-controlled and active-controlled comparisons analysed separately, prespecified exploratory subgroup and meta-regression analyses, GRADE certainty assessment, Risk of bias by Cochrane tool; certainty by GRADE
- Placebo-controlled and active-controlled comparisons analysed separately
- Prespecified exploratory subgroup and meta-regression analyses
- GRADE certainty assessment
- Risk of bias by Cochrane tool; certainty by GRADE
Pooled result
As reported in the abstract
Difference
−1.69 mmHg
95% CI −2.78 to −0.61
DPP-4ivs Placebo
difference −1.69 mmHg (95% CI −2.78 to −0.61)
Further pooled results
Seated SBP, renin-angiotensin-aldosterone system inhibitors (RAASi) co-administration subgroup (exploratory)
- Seated SBP lower, RAASi co-administration subgroup (39 studies; n = 4064)
- −1.60 mmHg (95% CI, −3.04 to −0.16; I 2 = 57%)
- Exploratory subgroup
- Moderate heterogeneity
DBP, baseline HbA1c ≤ 7.5% subgroup
- DBP estimate borderline, not considered robust evidence of benefit (22 studies; n = 1655)
- −0.85 mmHg (95% CI, −1.71 to 0.00)
Seated SBP and DBP, high-quality studies
- High-quality studies showed no detectable changes in seated SBP or DBP
Ambulatory BP
- Ambulatory BP (ABP) analyses showed no detectable differences (three publications, four studies)
Original publication
Efficacy of DPP ‐4 Inhibitors on Seated and Ambulatory Blood Pressure in Type 2 Diabetes Mellitus. Diabetes Obes Metab. Published 15 July 2026. doi:10.
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