Association of Adiposity Phenotypes With 27-Hydroxycholesterol and Sex Hormones: The Multiethnic Cohort Study
Authors' conclusion
Adiposity phenotypes, such as SAT, VAT, and liver fat, were differentially associated with circulating 27HC, while consistent directions of associations were seen for circulating hormones among postmenopausal women. Future studies are warranted to further understand the biology and relationships of 27HC and adiposity-related diseases.
Study context
- Population
- Postmenopausal women from the Multiethnic Cohort Adiposity Phenotype study
- Participants
- 912 women
- Outcome
- Associations of circulating 27HC, steroid hormones and SHBG with detailed adiposity phenotypes
Main finding
As reported in the abstract
Circulating 27HC by adiposity phenotype
- Total fat mass inversely associated with 27HC
- P trend = .003
- Subcutaneous adipose tissue (SAT) inversely associated with 27HC
- P trend = .006
- Superficial SAT inversely associated with 27HC
- P trend = 4.41 × 10-4
- Visceral adipose tissue (VAT) positively associated with 27HC
- P trend = .003
- Liver fat positively associated with 27HC
- P trend = .005
Observational data: associations, not effects.
Further findings
Sex hormones and sex hormone-binding globulin (SHBG) by adiposity phenotype
- All adiposity phenotypes associated with higher free estradiol and testosterone and lower SHBG
Subgroups by race and ethnicity
- Generally similar patterns of associations across race and ethnicity
Original publication
Association of Adiposity Phenotypes With 27-Hydroxycholesterol and Sex Hormones: The Multiethnic Cohort Study. J Clin Endocrinol Metab. Published 7 August 2024. doi:10.
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