Association of the estimated glucose disposal rate combined with a body shape index with all-cause and cardiovascular-specific mortality among individuals with cardiovascular-kidney-metabolic syndrome
Authors' conclusion
Both eGDR and ABSI are independent and combined predictors of mortality risk among individuals with CKM syndrome. Their combined use significantly improves risk stratification and machine learning models provide an effective tool for precise risk assessment in this population.
Study context
- Population
- Individuals with stage 0–4 cardiovascular-kidney-metabolic (CKM) syndrome, National Health and Nutrition Examination Survey (NHANES) 1999–2018
- Participants
- 18,186 individuals
- Exposure
- Combined estimated glucose disposal rate (eGDR) and a body shape index (ABSI) categories
- Outcome
- All-cause and cardiovascular-specific mortality
Methodological detailsNHANES 1999-2018, multivariable-adjusted Cox proportional hazards models, machine learning prediction models
- NHANES 1999-2018
- Multivariable-adjusted Cox proportional hazards models
- Machine learning prediction models
Main finding
As reported in the abstract
All-cause and cardiovascular-specific mortality by combined eGDR and ABSI
Low-eGDR and High-ABSIHazard ratio (95% CI)
All-cause mortality; highest risk
2.79(2.30–3.38)
Cardiovascular-specific mortality; highest risk
4.53(2.96–6.92)
- All-cause deaths during follow-up
- 2536
- Cardiovascular-specific deaths during follow-up
- 790
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Machine learning prediction (best: XGBoost) | XGBoost AUC all-cause mortality 0.877 · AUC cardiovascular-specific mortality 0.850 |
Machine learning prediction (best: XGBoost)
- XGBoost best performance among six machine learning algorithms
Original publication
Association of the estimated glucose disposal rate combined with a body shape index with all-cause and cardiovascular-specific mortality among individuals with cardiovascular-kidney-metabolic syndrome. Cardiovasc Diabetol. Published 12 March 2026. doi:10.
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