Association of depression, traditional risk factor control and genetic risk with incident cardiovascular disease among individuals with prediabetes: A population‐based prospective study from UK biobank
Authors' conclusion
Among individuals with prediabetes, both depression and suboptimal control of traditional risk factors are associated with an increased risk of CVD, independent of genetic susceptibility.
Study context
- Population
- Individuals with prediabetes free of prevalent cardiovascular disease (CVD), UK Biobank
- Participants
- 42,020 individuals
- Exposure
- Depression and risk factor control vs controlling 4-5 risk factors
- Outcome
- Incident CVD
- Follow-up
- Median 13.1 years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
CVD
Each group vs controlling 4-5 risk factorsMultivariable-adjusted HR (95% CI)
Depression
1.18(1.09–1.28)
Controlling 0-1 risk factor
1.44(1.29–1.60)
- Developed CVD
- 5865
- Coronary heart disease cases
- 4764
- Strokes
- 1415
Observational data: associations, not effects.
Further findings
Interaction between depression and risk factor control for CVD
- Relative excess risk due to interaction
- 0.16 (0.06-0.26)
- Depression ranked second in predicting CVD among selected risk factors
- Associations independent of genetic susceptibility to CVD
- Synergistic effect
Original publication
Association of depression, traditional risk factor control and genetic risk with incident cardiovascular disease among individuals with prediabetes: A population‐based prospective study from UK biobank. Diabetes Obes Metab. Published 25 February 2025. doi:10.
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