Glucagon-Like Peptide-1 Receptor Agonists and Risk for Depression in Older Adults With Type 2 Diabetes : A Target Trial Emulation Study
Authors' conclusion
Among older adults with T2D, the incidence of depression was relatively low. Use of GLP-1RAs was associated with a modestly lower risk for depression compared with use of DPP4is, but not SGLT2is.
Study context
- Population
- Adults aged ≥66 years with T2D, U.S. National Medicare administrative data, January 2014 to December 2020matched pairs
- Comparison
- GLP-1 RA initiation vs SGLT2i or DPP-4i initiation
- Outcome
- Incident depression
Methodological detailspropensity-score matched 1:1
- Propensity-score matched 1:1
Main finding
As reported in the abstract
Rate difference, per 1000 person-years (95% CI)
GLP-1RAvs SGLT2i14 665 matched pairs
3.48(−0.81 to 7.78)
GLP-1RAvs DPP4i13 711 matched pairs
−5.78(−10.49 to −1.07)
Hazard ratio (95% CI)
GLP-1RAvs SGLT2i14 665 matched pairs
1.07(0.98–1.18)
GLP-1RAvs DPP4i13 711 matched pairs
0.90(0.82–0.98)
Original publication
Glucagon-Like Peptide-1 Receptor Agonists and Risk for Depression in Older Adults With Type 2 Diabetes : A Target Trial Emulation Study. Ann Intern Med. Published 25 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →