Lipids & metabolic liver disease
Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression
Authors' conclusion
Participants with higher baseline and moderate-stable trajectory of the TyG index were associated with CAS progression. Long-term trajectories of the TyG index can help to identify individuals at a higher risk of CAS progression who deserve specific preventive and therapeutic approaches.
Study context
- Population
- Adults with multiple general health checks at Peking University Third Hospital, January 2011 to December 2020
- Participants
- 10,380 adults
- Exposure
- Triglyceride-glucose (TyG) index baseline and trajectories
- Outcome
- Carotid atherosclerosis (CAS) progression
- Follow-up
- Median 757 days
Methodological detailslongitudinal, latent class trajectory modeling
- Longitudinal
- Latent class trajectory modeling
Main finding
As reported in the abstract
CAS progression
Each group vs low-stableHazard ratio (95% CI)
Moderate-stablemultivariate adjusted
1.139(1.021–1.272)
High-increasingtended to be associated
1.206(0.961–1.513)
- Participants developing carotid atherosclerosis (CAS) progression
- 1813
- HR per 1-SD increase in baseline TyG index, adjusted for traditional cardiovascular disease (CVD) risk factors (7% higher risk)
- 1.067 (95% CI 1.006-1.132)
Observational data: associations, not effects.
Further findings
TyG index quartiles and CAS progression
- Similar results when TyG index expressed as quartiles
Original publication
Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression. Cardiovasc Diabetol. Published 31 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →