Reproductive endocrinology

Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women

Cardiovasc DiabetolPublished Cohort study

Main finding · Incident CVDResult — go to the resultHazard ratio 1.70 95% CI 1.21–2.38

Authors' conclusion

Higher TyG index at baseline as a marker of insulin resistance (IR), is associated with higher risk of future CVD among postmenopausal women. The TyG index may serve as a simple and easy marker for early identification of high-risk individuals in the postmenopausal women.

Study context

Population
Postmenopausal women; TyG index = ln (TG [mg/dL] × fasting blood glucose [mg/dL]/2)
Participants
7,741 women
Exposure
TyG index quartiles Q2–Q4 vs Q1
Outcome
Incident CVD
Follow-up
Median 12 years

Main finding

As reported in the abstract

Hazard ratio

1.70

95% CI 1.21–2.38

Q4vs Q1
HR 1.70 (95% CI 1.21–2.38)

Observational data: associations, not effects.

Further findings

Subgroups by age at menopause (<50 y; ≥50 y) and obesity status

Q4 significantly associated with cardiovascular disease (CVD) risk regardless of age at menopause and obesity status

Original publication

Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women. Cardiovasc Diabetol. Published 30 January 2023. doi:10.1186/s12933-023-01753-3

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