Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study
Authors' conclusion
Our study revealed that within-person changes in fat mass and lean mass were associated with increased insulin sensitivity and reduced 2-h glucose concentrations, respectively, among high-risk Latino youth. The impact of reductions in regional and organ fat deposition on T2D risk factors warrants further examination.
Study context
- Population
- Latino youth aged 12–16 years with obesity (30 males, 25 females); groups combined for analysis30 males · 25 females
- Participants
- 39 vs 16
- Comparison
- Within-person changes in total, regional and organ fat vs changes in T2D-related biomarkers
- Lifestyle interventionn = 39
- Usual caren = 16reference
- Primary endpoint
- Association of within-person changes in total, regional and organ fat (DEXA; hepatic and pancreatic fat by MRI) with changes in T2D risk factors (insulin sensitivity, beta-cell function, post-challenge glucose)
Methodological detailslongitudinal, within-person analysis
- Longitudinal
- Within-person analysis
Primary result
As reported in the abstract
Associations of body composition changes with T2D risk factor changes
Change in fat mass vs change in insulin sensitivity, β
−0.45
p < 0.001
Change in lean mass vs change in 2-h glucose, β
−0.50
p = 0.02
Further findings
Changes over intervention
- Significant changes in %body fat, lean mass, insulin sensitivity and 2-h glucose
Original publication
Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study. Pediatr Obes. Published 17 November 2024. doi:10.
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