Association between thyroid hormone and pre-sarcopenic obesity in euthyroid population: a prospective cohort study
Main finding · New-onset pre-sarcopenic obesityResult — go to the resultRelative risk 1.82 95% CI 1.20–2.76Authors' conclusion
Elevated serum fT3 levels were associated with increased risks of pre-sarcopenic obesity and pre-sarcopenia in euthyroid Chinese participants.
Study context
- Population
- Euthyroid community residents aged over 40 years (42.3% men), recruited 2013–2014 and re-examined 2015–2016; Chinese
- Participants
- 1,280 residents
- Exposure
- Highest vs lowest tertile of baseline serum FT3
- Outcome
- Incident pre-sarcopenic obesity (coexistence of pre-sarcopenia and visceral obesity; Visceral fat area (VFA) by MRI, skeletal muscle mass by bioelectrical impedance)
- Follow-up
- Mean 2.1 years
Methodological detailscommunity-based
- Community-based
Main finding
New-onset pre-sarcopenic obesity
Relative risk
1.82
95% CI 1.20–2.76
Highest tertilevs Lowest tertile
RR 1.82 (95% CI 1.20–2.76)
As reported in the abstract
- Developed new-onset pre-sarcopenic obesity (all participants)
- 127 (14.8%)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| New-onset pre-sarcopenia · mean follow-up 2.1 years | 1.49 (1.04–2.15) | |
| 0.512Relative risk (log scale) |
- New-onset pre-sarcopenia — Developed new-onset pre-sarcopenia (all participants)
- 156 (21.3%)
New-onset visceral obesity · mean follow-up 2.1 years
- Developed new-onset visceral obesity (all participants)
- 120 (20.1%)
Per 1 SD increase in serum FT3 over 2.1 years · mean 2.1 years
- RR for incident pre-sarcopenic obesity
- 1.40 (95% CI 1.28-1.53)
- RR for incident pre-sarcopenia
- 1.29 (95% CI 1.18-1.40)
Original publication
Association between thyroid hormone and pre-sarcopenic obesity in euthyroid population: a prospective cohort study. Eur Thyroid J. Published 11 June 2026. doi:10.
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