Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity
Authors' conclusion
In this cross-sectional study, SO was associated with larger EAT area and higher EAT radiodensity. These findings support the presence of a distinct EAT phenotype in SO and suggest that CT-derived EAT measures may be useful imaging markers that warrant prospective validation.
Study context
- Population
- Adults undergoing health examinations
- Participants
- 1,678 adults
- Exposure
- Sarcopenic obesity vs normal phenotype
- Sarcopenic obesity (SO)n = 45
- Outcome
- EAT area and radiodensity (non-contrast chest CT)
Main finding
As reported in the abstract
Beta (epicardial adipose tissue (EAT) area)
6.93 cm²
95% CI 5.84–8.03
multivariable-adjusted; larger with SO
Beta (EAT radiodensity)
9.23 HU
95% CI 8.03–10.43
multivariable-adjusted; higher (less negative) with SO
Observational data: associations, not effects.
Further findings
Sarcopenia × obesity interaction
- Interaction beta for EAT area
- 1.53 cm² (95% CI, 0.05 to 3.01; P for interaction = 0.042)
- No significant interaction for EAT radiodensity
Grip strength and EAT radiodensity (sex-stratified)
- Grip strength showed a pronounced non-linear association with EAT radiodensity
Original publication
Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity. Cardiovasc Diabetol. Published 10 June 2026. doi:10.
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