Association Between Relative Cord Hyperleptinemia and Offspring Outcomes in Pregnant Women With Overweight or Obesity
Authors' conclusion
Relative cord hyperleptinaemia was associated with reduced offspring BMI among males.
Study context
- Population
- Infants of pregnant women with overweight or obesity in the DALI trial; maternal pre-pregnancy BMI 33.7 ± 4.2 kg/m², 52% male
- Participants
- 323 infants
- Comparison
- Top vs low tertile of cord leptin-to-fat mass ratio
Primary result
As reported in the abstract
- C-peptide-to-glucose ratio elevated in TT vs LT among males (not females)
- Birthweight, fat mass percentage and BMI z-scores (at age 1 only) lower in TT vs LT among males
- TT vs LT: P < 0.001
- TT vs LT: P = 0.045
- TT vs LT: P = 0.008
- TT vs LT: P = 0.03
Further findings
Median
| Outcome | Female | Male | P value |
|---|---|---|---|
| Cord leptin-to-fat mass ratio, female vs male offspring · birth | 21.4 (IQR 13.4–30.99) | 15.5 (IQR 8.3–25.9) | P < 0.001 |
Cord leptin-to-fat mass ratio, female vs male offspring · birth
- Female offspring had higher cord leptin, fat mass percentage and leptin-to-fat mass ratio
Cord leptin and fat mass percentage, TT vs LT
- TT (58% females) had higher cord leptin but similar fat mass percentage vs LT
Original publication
Association Between Relative Cord Hyperleptinemia and Offspring Outcomes in Pregnant Women With Overweight or Obesity. Pediatr Obes. Published 21 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →