Association between prediabetes, frailty, and cardiovascular outcomes in the oldest old: A retrospective nationwide cohort study
Authors' conclusion
In the oldest old (aged 80+), prediabetes is associated with reduced all-cause mortality but slightly increased risks of HF and stroke. Frailty modulates prediabetes progression, with non-frail individuals more likely to develop diabetes.
Study context
- Population
- Individuals aged 80+ (61.4% females, mean age 84.1 ± 3.7 years); baseline periods 2005–2006 and 2014–2015, follow-up 2007–2013 and 2016–2022; frailty by cumulative deficit method
- Participants
- 126,323 individuals
- Exposure
- Prediabetes vs normoglycaemia
- Prediabetesn = 34,151
- Normoglycemicn = 92,172reference
- Outcome
- Myocardial infarction (MI), stroke, heart failure (HF) and all-cause mortality
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Each group vs normoglycemicEstimate (95% CI)
Prediabetes
HR (all-cause mortality) 0.86(0.85–0.88)
Prediabetes
HR (MI) 0.98(0.94–1.02)
Prediabetes
HR (HF) 1.06(1.03–1.09)
Prediabetes
HR (stroke) 1.06(1.02–1.10)
Observational data: associations, not effects.
Further findings
Glycaemic trajectory of prediabetes · seven years
- Progressed to diabetes
- 13.5%
- Regressed to normoglycemia
- 47.4%
- Remained with prediabetes
- 39.1%
Progression to diabetes by frailty
- Non-frail vs severely frail: more likely to progress to diabetes
- 15.0% vs. 9.3%
Original publication
Association between prediabetes, frailty, and cardiovascular outcomes in the oldest old: A retrospective nationwide cohort study. Diabetes Res Clin Pract. Published 9 April 2025. doi:10.
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