Connecting underlying factors in the associations between perceived neighborhood social environments and type 2 Diabetes: Serial mediation analyses
Authors' conclusion
This study may be the first to demonstrate underlying potential mechanisms through which socially cohesive and safe neighborhoods lower the risk of T2D. These pathways present potential targets for interventions to reduce the risk.
Study context
- Population
- Midlife in the United States (MIDUS 3 [2013–2014] and MIDUS 3 Biomarker Project [2017–2022]) participants; T2D per ADA criteria
- Participants
- 518 participants
- Exposure
- Perceived neighborhood social cohesion and safety (higher = more favorable) and T2D, mediated via PA, BMI, stress, depression and c-reactive protein (CRP)
- Outcome
- T2D (yes/no) per ADA criteria; indirect (serially mediated) associations with perceived neighborhood social cohesion and safety
Methodological detailsserial mediation analyses, MIDUS 3 and MIDUS 3 Biomarker Project data
- Serial mediation analyses
- MIDUS 3 and MIDUS 3 Biomarker Project data
Main finding
As reported in the abstract
Higher social cohesion indirectly related to lower likelihood of T2D, serially mediated through PA, BMI and CRP: OR
1.00
95% BC CI 0.99, 1.00
Higher social cohesion indirectly associated with lower likelihood of T2D, serially mediated via stress, depression and CRP: OR
0.98
95% BC CI 0.96, 1.00p < 0.05
Higher safety indirectly associated with lower likelihood of T2D, serially mediated via stress, depression and CRP: OR
0.98
95% BC CI 0.96, 1.00p < 0.05
Observational data: associations, not effects.
Original publication
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