Association Between Per- and Polyfluoroalkyl Substance Exposures and Thyroid Homeostasis Parameters
Authors' conclusion
This study revealed that PFAS exposures may affect peripheral thyroid hormone sensitivity instead of central among US general adults, enhancing our understanding of the correlation between PFAS exposure and thyroid hormones and providing insights into potential health implications.
Study context
- Population
- US adults, NHANES 2007–2008 and 2011–2012
- Participants
- 2,386 adults
- Exposure
- PFAS exposures vs thyroid homeostasis parameters
- Outcome
- Thyroid homeostasis parameters: central and peripheral thyroid hormone sensitivity
Methodological detailssurvey-weighted linear regression, weighted quantile sum (WQS) and quantile g-computation (QGC) mixture models
- Survey-weighted linear regression
- WQS and QGC mixture models
Main finding
As reported in the abstract
Associations of PFAS with thyroid homeostasis parameters
PFAS coexposure and FT3/FT4, WQS model
β = 0.013
P < .001
PFAS coexposure and SPINA-GD, WQS model
β = 1.230
P < .001
PFAS per quantile and FT3/FT4, QGC model
β = 0.004
P = .002
PFAS per quantile and SPINA-GD, QGC model
β = 0.392
P = .008
Observational data: associations, not effects.
Original publication
Association Between Per- and Polyfluoroalkyl Substance Exposures and Thyroid Homeostasis Parameters. J Clin Endocrinol Metab. Published 18 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →