Thyroid disease

Treatment of Hypothyroidism by Age and Sex in the United States: A NHANES and Optum Claims Data Analysis

Endocr PractPublished Cross-sectional study

Authors' conclusion

This study provides important updates regarding treatment of OHT and highlights treatment disparities, especially among men and women of reproductive age, using both total and insured population estimates.

Study context

Population
US adults with overt hypothyroidism (TSH > 4.0 mIU/L and FT4 < 0.8 ng/dL or evidence of overt HT (OHT) treatment)
Exposure
NHANES vs Optum Claims data (OCD)
Outcome
Treatment rates of overt hypothyroidism (levothyroxine or liothyronine)
Methodological detailsNHANES (2009-2012) and Optum Claims data (2012-2019), stratified by age group and sex
  • NHANES (2009-2012) and Optum Claims data (2012-2019)
  • Stratified by age group and sex

Main finding

As reported in the abstract

Treatment rate of OHT

OCD

> 80%

Overall receiving treatment
> 72%
OCD: treatment similar across age group and sex
> 78% treated

Observational data: associations, not effects.

Further findings

NHANES treatment rate by age, females vs males

Age 18-44, females vs males
47.3% vs 39.9%
Age 45-59, females vs males
76.8% vs 51.1%
Age ≥ 60, females vs males
91.9% vs 65.6%
  • Treatment rates increased with advancing age, consistently higher in females

NHANES treatment rate, not privately/Medicare insured

Overall
50%
Age ≥ 60 (highest)
> 75%

NHANES treatment rate, reproductive-aged women

All
< 50%
Uninsured
22%

Original publication

Treatment of Hypothyroidism by Age and Sex in the United States: A NHANES and Optum Claims Data Analysis. Endocr Pract. Published 10 December 2024. doi:10.1016/j.eprac.2024.12.004

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