Association between the newly proposed triglyceride glucose-a body shape index (TyG-ABSI) and atherosclerotic cardiovascular disease in the general population: modest diagnostic improvement compared with traditional TyG-related parameters
Authors' conclusion
This study indicates a significant positive correlation between TyG-ABSI and ASCVD in the general population. Moreover, TyG-ABSI demonstrates modest improvement in discrimination compared to traditional TyG parameters, identifying additional high-risk individuals via reclassification.
Study context
- Population
- General population, National Health and Nutrition Examination Survey (NHANES) 1999–2018; Atherosclerotic cardiovascular disease (ASCVD) defined by self-reported physician diagnosis of coronary heart disease (CHD), angina pectoris, myocardial infarction (MI) or stroke
- Participants
- 22,466 participants
- Exposure
- TyG-ABSI vs traditional TyG-related parameters for ASCVD
- Outcome
- Association of TyG-ABSI with ASCVD and its subtypes
Methodological detailsnationally representative, NHANES 1999-2018, weighted logistic regression
- Nationally representative
- NHANES 1999-2018
- Weighted logistic regression
Main finding
As reported in the abstract
ASCVD and subtypes, per SD increase in TyG-ABSI (fully adjusted)
- ASCVD: OR per SD increase
- 1.15 (95% CI 1.09-1.22)
- CHD: OR
- 1.14 (95% CI 1.05-1.24)
- Angina pectoris: OR
- 1.10 (95% CI 1.01-1.21)
- MI: OR
- 1.15 (95% CI 1.06-1.25)
- Linear dose-response for ASCVD and all subtypes
- all p-trend < 0.05
Observational data: associations, not effects.
Further findings
Discrimination (ROC AUC) of TyG-ABSI
- TyG-ABSI had the highest AUC across all outcomes; ASCVD AUC
- 0.69
- CHD AUC
- 0.70
- Angina pectoris AUC
- 0.69
- MI AUC
- 0.70
- Stroke AUC
- 0.65
Reclassification (net reclassification improvement (NRI), integrated discrimination improvement (IDI)) vs traditional TyG parameters
- ASCVD: additional patients correctly reclassified by NRI, vs TyG-WHtR to vs TyG-BMI
- 7.88% to 16.36%
- Modest but significant improvement in discrimination over traditional TyG parameters for ASCVD and subtypes (significant NRI and IDI)
Subgroup and sensitivity analyses
- Association robust across demographic, lifestyle and clinical subgroups and in sensitivity analyses
Original publication
Association between the newly proposed triglyceride glucose-a body shape index (TyG-ABSI) and atherosclerotic cardiovascular disease in the general population: modest diagnostic improvement compared with traditional TyG-related parameters. Cardiovasc Diabetol. Published 18 January 2026. doi:10.
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