The predictive value of C-reactive protein-triglycerides-glucose index-waist-to-height ratio for stroke: a nationwide cohort study
Authors' conclusion
The consistent positive linear association between CTI-WHtR and stroke risk highlights its potential utility as a clinical and public health indicator. Monitoring and maintaining optimal CTI-WHtR levels may aid in identification of individuals at elevated stroke risk. Graphical Abstract.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study, 2011–2020
- Participants
- 10,070 participants
- Exposure
- CTI-waist-to-height ratio (CTI-WHtR) quartiles and trajectories; CTI derivatives vs standalone CTI for stroke prediction
- Outcome
- Incident stroke
- Follow-up
- 2011–2020
Methodological detailsnationwide, China Health and Retirement Longitudinal Study (CHARLS)
- Nationwide
- China Health and Retirement Longitudinal Study (CHARLS)
Main finding
As reported in the abstract
Incident stroke vs CTI-WHtR
Odds ratio (95% CI)
Per one-unit increase in CTI-WHtR
1.73(1.45–2.07)
Q4vs Q1
2.20(1.71–2.83)
- Incident stroke during follow-up
- 950 participants (9.43%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Stroke by CTI-WHtR trajectoryCluster 2vs Cluster 1 | 1.69 (1.34–2.13) | |
| Stroke by CTI-WHtR trajectoryCluster 3vs Cluster 1 | 1.26 (1.06–1.52) | |
| 0.512Odds ratio (log scale) |
Dose-response of CTI-WHtR and stroke risk
- Clear dose-response; risk increased sharply when CTI-WHtR exceeded
- 2.52
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The predictive value of C-reactive protein-triglycerides-glucose index-waist-to-height ratio for stroke: a nationwide cohort study. Cardiovasc Diabetol. Published 17 January 2026. doi:10.
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