Association between interleukin-6, soluble-urokinase-plasminogen-activator-receptor (suPAR), and high-sensitivity C-reactive-protein (hsCRP) with subclinical left ventricular dysfunction in type 1 diabetes: The Thousand & 1 study
An erratum to this article was published (Diabetes Res Clin Pract, Aug 2026 ↗)
Authors' conclusion
Inflammatory biomarkers are independently associated with subclinical left ventricular dysfunction. Chronic inflammation may contribute to the development of myocardial dysfunction in T1D.
Study context
- Population
- Individuals with T1D without known heart disease; 52 % male, mean age 49 ± 14 years
- Participants
- 962 individuals
- Exposure
- Inflammatory biomarkers and echocardiographic LV function
- Outcome
- Echocardiographic E/e'
Main finding
As reported in the abstract
E/e' (fully adjusted linear regression, beta coefficients)
- Mean E/e' (all participants)
- 7 ± 3
- IL-6, beta (95% CI 0.1-0.3), P = 0.001
- 0.2
- suPAR, beta (95% CI 0.1-0.7), P = 0.011
- 0.5
- hsCRP, beta (95% CI 0.0-0.2), P = 0.023
- 0.1
- Elevated IL-6 and suPAR, beta (95% CI 0.7-2.0), P < 0.001
- 1.3
- Elevated all three, beta (95% CI 1.1-2.7), P < 0.001
- 1.9
Observational data: associations, not effects.
Secondary outcomes
Global longitudinal strain (GLS) (fully adjusted, beta coefficients)
- Mean GLS (all participants)
- 18 ± 3
- IL-6, beta (95% CI −0.7 to 0.0), P = 0.039
- −0.4
- IL-6 and hsCRP, beta (95% CI −1.7 to −0.4), P = 0.007
- −1.0
- All three, beta (95% CI −2.0 to −0.3), P = 0.009
- −1.1
Original publication
Association between interleukin-6, suPAR, and hsCRP with subclinical left ventricular dysfunction in type 1 diabetes: The Thousand & 1 study. Diabetes Res Clin Pract. Published 3 March 2025. doi:10.
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