Association Between Glycemic Status and the Risk of Kidney Cancer in Men and Women: A Nationwide Cohort Study
Authors' conclusion
Glycemic status and kidney cancer risk exhibited a dose-response association in women. Diabetes, but not prediabetes, was associated with an increased risk in men. Although women have a lower risk of kidney cancer than men, women with even prediabetes have an increased risk. These findings should not be overlooked when monitoring for kidney complications.
Study context
- Population
- Adults without cancer who underwent national health screening in 2009, followed up until 31 December 2018
- Participants
- 9,492,331 adults
- Exposure
- Diabetes and prediabetes vs normoglycemia, in men and women
- Outcome
- Incident kidney cancer
- Follow-up
- Until 31 December 2018
Methodological detailsmultivariable Cox proportional hazard regression, adjusted for potential confounders
- Multivariable Cox proportional hazard regression
- Adjusted for potential confounders
Main finding
As reported in the abstract
Kidney cancer risk by glycemic status, never-smokers
Each group vs normoglycemiaAdjusted hazard ratio (95% CI)P value
Diabetesmen, never-smokers
1.25(1.12–1.38)
Prediabetesmen, never-smokers
1.06(0.97–1.15)
Diabeteswomen, never-smokers
1.34(1.21–1.49)
P < 0.01for trendPrediabeteswomen, never-smokers
1.19(1.10–1.29)
P < 0.01for trendObservational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Kidney cancer risk with diabetes, smokersDiabetesvs NormoglycemiaMen, smokers; 49% increased risk | 1.49 (1.37–1.61) | |
| Kidney cancer risk with diabetes, smokersDiabetesvs NormoglycemiaWomen, smokers; 85% increased risk | 1.85 (1.26–2.73) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Incidence rate, never-smokers with normoglycemia, men vs women
- Male-to-female incidence rate ratio
- 2.1:1
- Men vs women incidence
- 17.8 vs. 8.5/100,000 person-years
Incident kidney cancer cases · 78.1 million person-years of follow-up
- Men
- 8,834
- Women
- 3,547
Original publication
Association Between Glycemic Status and the Risk of Kidney Cancer in Men and Women: A Nationwide Cohort Study. Diabetes Care. Published 9 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →