Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
Authors' conclusion
AGE accumulation was independently associated with prevalent heart failure. Among individuals free of heart failure, AGEs were associated with cardiac function, in particular systolic function. This association was present in participants with and without diabetes and was more prominent in those with diabetes.
Study context
- Population
- Participants of the population-based Rotterdam Study; Left ventricular (LV) function analyses among individuals free of HF (N=2362)2,362 free of HF
- Participants
- 2,426 participants
- Exposure
- Higher vs lower skin autofluorescence, per one unit
- Outcome
- Prevalent HF
Methodological detailspopulation-based, adjusted for traditional cardiovascular risk factors
- Population-based
- Adjusted for traditional cardiovascular risk factors
Main finding
As reported in the abstract
Multivariable adjusted OR per one unit higher skin autofluorescence (SAF)
OR 2.90
95% CI 1.80, 4.62
Observational data: associations, not effects.
Further findings
LV ejection fraction per one unit increase in SAF, individuals without HF
- Mean difference (β)
- −0.98% (95% CI −1.45%, −0.50%)
LV ejection fraction per one unit increase in SAF, by diabetes status
- With diabetes, β
- −1.84% (95% CI −3.10%, −0.58%)
- Without diabetes, β
- −0.78% (95% CI −1.29%, −0.27%)
- Association stronger among participants with diabetes
Diastolic function parameters
- Associations of SAF with diastolic function parameters not apparent, except in men with diabetes
Original publication
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