Association between estimated glucose disposal rate and lower extremity arterial disease in type 2 diabetes: A nationwide cross‐sectional study from China
Authors' conclusion
eGDR demonstrated a significant inverse L-shaped association with LEAD in patients with T2DM. These findings support the clinical utility of eGDR as a practical indicator of LEAD risk screening and management. Patients with lower eGDR may benefit from insulin-sensitising therapies, which could reduce both glucose levels and the risk of LEAD.
Study context
- Population
- Adults aged ≥50 years with T2D, China DIA-LEAD study
- Participants
- 7,482 adults
- Exposure
- Estimated glucose disposal rate (eGDR) quartiles
- Outcome
- LEAD, defined by ankle-brachial index <0.9 or >1.3
Methodological detailsnationwide, multivariate logistic regression, restricted cubic spline models
- Nationwide
- Multivariate logistic regression
- Restricted cubic spline models
Main finding
As reported in the abstract
LEAD
Adjusted odds ratio (95% CI)
Per 1-unit eGDR increase24% lower LEAD risk
0.76(0.70–0.84)
Per 1-unit eGDR increase, as printed
- Q1 vs Q4 · fully adjusted
- fold higher lower extremity arterial disease (LEAD) risk 2.23 (95% CI 1.47–3.37)
- Progressively higher LEAD prevalence in lower eGDR quartiles
- all p < 0.001
- L-shaped relationship, sharp risk escalation at eGDR < 8 mg/kg/min
- p for nonlinearity = 0.003
Observational data: associations, not effects.
Further findings
HbA1c
- HbA1c — Worse glycaemic control and greater comorbidity burden in lower quartiles
- all p < 0.001
Subgroup analyses
- Consistency across populations
- all p for interaction >0.05
Original publication
Association between estimated glucose disposal rate and lower extremity arterial disease in type 2 diabetes: A nationwide cross‐sectional study from China. Diabetes Obes Metab. Published 9 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →