Association between long-term serum uric acid variability and diabetic retinopathy: A prospective study in patients with Type 1 and Type 2 diabetes
Authors' conclusion
High long-term variability is significantly associated with the development and worsening of DR in DM patients, suggesting the importance of the benefits of continuous serum uric acid control.
Study context
- Population
- Patients with T1D or T2D without proliferative diabetic retinopathy (DR) at baseline, Shanghai General Hospital, followed ≥1 year
- Participants
- 730 patients
- Exposure
- Higher vs lowest quantile of serum uric acid average real variability (ARV)
- Outcome
- Development and/or worsening of DR (fundus photography)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
DR worsening
Hazard ratio (95 % CI)P value
Q3vs Q1
2.2(1.2206∼3.8201)
P = 0.008Q4vs Q1
2.74(1.1339∼3.7255)
P = 0.017- DR development and progression more likely with higher serum uric acid (SUA) ARV (Kaplan-Meier)
- Log-rank p-value of 0.0055
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between long-term serum uric acid variability and diabetic retinopathy: A prospective study in patients with Type 1 and Type 2 diabetes. Diabetes Res Clin Pract. Published 3 June 2025. doi:10.
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