Risk factors for corneal nerve fiber loss in Chinese patients with type 2 diabetes mellitus
Authors' conclusion
HbA1c, CV, and LDL-C levels are independently associated with CNFL in T2DM patients. Combining three factors showed good performance for detecting abnormal CNFL and these may accordingly serve as intervention targets for the early DPN prevention and treatment.
Study context
- Population
- Patients with T2D evaluated by corneal confocal microscopy; 80 underwent CGM for 3 days80 with CGM
- Participants
- 150 patients
- Exposure
- HbA1c vs coefficient of variation (CV) vs low-density lipoprotein cholesterol (LDL-C)
- Outcome
- Glucose and lipid factors affecting corneal nerve fiber length (CNFL) and their diagnostic value for abnormal CNFL
Main finding
As reported in the abstract
Diagnostic performance for abnormal CNFL
| Group | AUC | Sensitivity | Specificity | Optimal cutoff |
|---|---|---|---|---|
| HbA1c | 0.649 | 0.804 | 0.458 | 7.55 |
| CV | 0.643 | 0.625 | 0.750 | 25.06 |
| LDL-C | 0.642 | 0.857 | 0.417 | 1.985 |
AUC
HbA1c0.649
CV0.643
LDL-C0.642
Sensitivity
HbA1c0.804
CV0.625
LDL-C0.857
Specificity
HbA1c0.458
CV0.750
LDL-C0.417
Optimal cutoff
HbA1c7.55
CV25.06
LDL-C1.985
Observational data: associations, not effects.
Original publication
Risk factors for corneal nerve fiber loss in Chinese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 2 June 2025. doi:10.
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