Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia
Authors' conclusion
Different changes in eGDR level are associated with different risks of incident CVD. Dynamic monitoring of eGDR level is of significant importance for the CVD prevention and treatment.
Study context
- Population
- Individuals from UK Biobank and China Health and Retirement Longitudinal Study (CHARLS) with two measurements of estimated glucose disposal rate (eGDR)11,682 UK Biobank
- Exposure
- Classes of eGDR change vs persistently high eGDR
- Outcome
- Incident CVD
- Follow-up
- Median 9.7 years (UK Biobank) and 3.0 years (CHARLS)
Methodological detailstwo prospective cohorts (UK Biobank and CHARLS), K-means clustering of eGDR change, Cox proportional hazard models adjusted for potential confounders
- Two prospective cohorts (UK Biobank and CHARLS)
- K-means clustering of eGDR change
- Cox proportional hazard models adjusted for potential confounders
Main finding
As reported in the abstract
Each group vs class 1Hazard ratio (95% CI)
Class 3UK Biobank
2.79(2.15–3.62)
Class 4UK Biobank
3.19(2.50–4.08)
Class 3CHARLS
1.66(1.29–2.13)
Class 4CHARLS
1.69(1.34–2.14)
Observational data: associations, not effects.
Further findings
- Lower cumulative eGDR associated with elevated risk of incident cardiovascular disease (CVD)
- Dose-response curve between cumulative eGDR and CVD risk showed a negative linear relationship
Original publication
Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia. Cardiovasc Diabetol. Published 7 November 2024. doi:10.
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