Association between stress hyperglycemia ratio and postoperative major adverse cardiovascular and cerebrovascular events in noncardiac surgeries: a large perioperative cohort study
Authors' conclusion
In this large perioperative cohort study, we observed that both higher and lower SHR were associated with an increased risk of MACCE within 30 and 90 days after NCS, especially in patients without diabetes. These findings suggest that SHR potentially plays a key role in stratifying cardiovascular and cerebrovascular risk after NCS.
Study context
- Population
- Patients undergoing general anesthesia for noncardiac surgery
- Participants
- 12,899 patients
- Exposure
- Stress hyperglycemia ratio (SHR) tertiles
- Outcome
- MACCE: angina, acute MI, cardiac arrest, arrhythmia, HF, stroke, or in-hospital all-cause mortality
- Follow-up
- Within 30 days postoperatively
Main finding
As reported in the abstract
MACCE · 30 days
Each group vs T2Adjusted risk increase (times) (95% CI)
T3
1.34(1.08–1.66)
T1
1.35(1.08–1.68)
- Major adverse cardiovascular and cerebrovascular events (MACCE) within 30 days, all participants
- 592 (4.59%)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted risk increase (times) (95% CI) | |
|---|---|---|
| MACCE, non-diabetes subgroup · 30 daysT3vs T2Exploratory subgroup analysis | 1.60 (1.21–2.12) | |
| MACCE, non-diabetes subgroup · 30 daysT1vs T2Exploratory subgroup analysis | 1.61 (1.21–2.14) | |
| −10123Difference (linear scale) |
- MACCE, non-diabetes subgroup — U-shaped nonlinear relationship, 30 days
- P for nonlinear = 0.010
- MACCE, non-diabetes subgroup — U-shaped nonlinear relationship, 90 days
- P for nonlinear = 0.008
MACCE within 90 days, all participants
- MACCE within 90 days
- 1,045 (8.10%)
MACCE, non-diabetes subgroup · 30 days
- Similar results within 90 days in the non-diabetes group
MACCE, diabetes subgroup · 30 days
- No statistically significant increase in risk
- Exploratory subgroup analysis
Original publication
Association between stress hyperglycemia ratio and postoperative major adverse cardiovascular and cerebrovascular events in noncardiac surgeries: a large perioperative cohort study. Cardiovasc Diabetol. Published 2 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →