Cardiovascular disease modifies the relationship between systolic blood pressure and outcomes in people with diabetes
Authors' conclusion
Results of the current study suggest that the relationship between baseline SBP with MACE and all-cause death varied significantly by baseline CVD status.
Study context
- Population
- Community adults with diabetes, with or without existing cardiovascular disease (CVD)
- Participants
- 16,431 adults
- Exposure
- Baseline systolic blood pressure (SBP) categories, by CVD status
- Outcome
- MACE and all-cause death
- Follow-up
- Median 3.4 (IQR 2.6, 4.3) years
Methodological detailscommunity-based, multivariable-adjusted Cox proportional hazard models, restricted cubic spline
- Community-based
- Multivariable-adjusted Cox proportional hazard models
- Restricted cubic spline
Main finding
As reported in the abstract
median 3.4 years
- Free of CVD: Major adverse cardiovascular event (MACE) risk increased as SBP category advanced (120-129, 130-139, ≥ 140 vs < 120 mmHg); linear relationship (P-nonlinear = 0.75)
- P-trend < 0.001
- Free of CVD: all-cause death risk lower with SBP 120-139 and 140-159 mmHg, higher with SBP ≥ 160 mmHg; U-shaped relationship
- P-nonlinear < 0.001
Observational data: associations, not effects.
Further findings
Events during follow-up · median 3.4 years
- MACE
- 2145 (13.1 %)
- All-cause death
- 1025 (6.2 %)
Original publication
Cardiovascular disease modifies the relationship between systolic blood pressure and outcomes in people with diabetes. Diabetes Res Clin Pract. Published 30 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →