Association between the cumulative estimated glucose disposal rate and incident stroke in adults aged 50 and above without diabetes: a prospective nationwide cohort study in China
Authors' conclusion
Among adults aged 50 years or older without diabetes, lower cumulative eGDR levels were significantly associated with an increased risk of incident stroke.
Study context
- Population
- Adults aged ≥50 years without history of diabetes, China Health and Retirement Longitudinal Study (CHARLS); median age 61 years, 48.7% men
- Participants
- 3,808 adults
- Exposure
- Cumulative estimated glucose disposal rate (eGDR) quartiles
- Outcome
- Incident stroke
Methodological detailsnationwide, CHARLS
- Nationwide
- CHARLS
Main finding
As reported in the abstract
Incident stroke by cumulative eGDR
Hazard ratio (95% CI)P value
Cumulative eGDR (per SD increase)adjusted
0.69(0.60–0.80)
P < 0.001Q2vs Q1
0.63(0.46–0.88)
P = 0.006Q3vs Q1
0.41(0.28–0.60)
P < 0.001Q4vs Q1
0.35(0.23–0.52)
P < 0.001- Significant inverse and nonlinear association (RCS)
- P < 0.001; P for nonlinearity = 0.021
Observational data: associations, not effects.
Original publication
Association between the cumulative estimated glucose disposal rate and incident stroke in adults aged 50 and above without diabetes: a prospective nationwide cohort study in China. Cardiovasc Diabetol. Published 19 December 2025. doi:10.
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