Arterial collagen IV and laminin levels associate with type 2 diabetes, glycemic control, major adverse cardiac events, and mortality in coronary bypass patients
Authors' conclusion
We demonstrate that arterial basement membrane protein accumulation is related to glycemic status in T2DM. Furthermore, the observed associations between collagen IV and laminin levels and clinical outcomes support the notion that generalized alterations in arterial basement membranes may contribute to the development of cardiovascular disease.
Study context
- Population
- Patients undergoing coronary artery bypass graft surgery, Odense University Hospital, Denmark, 2008–2018; 27% with T2D27% T2D
- Participants
- 668 patients
- Exposure
- T2D vs non-diabetic controls
- Outcome
- Arterial basement membrane proteins (collagen IV, laminin, perlecan)
Methodological detailssingle-centre, proteomic analysis of internal thoracic artery samples, Seventeen vascular proteins quantified by liquid chromatography tandem mass spectrometry
- Single-centre
- Proteomic analysis of internal thoracic artery samples
- Seventeen vascular proteins quantified by liquid chromatography tandem mass spectrometry
Main finding
As reported in the abstract
- Collagen IV, laminin and perlecan levels significantly elevated in T2D vs non-diabetic controls
- In T2D, strong correlations of collagen IV and laminin with HbA1c; correlations with plasma lipids, blood pressure and body mass index (BMI) weak or absent
- Collagen IV and laminin associated with all-cause mortality and MACE up to 14 years after surgery, adjusted for age, sex and comorbidities
Observational data: associations, not effects.
Original publication
Arterial collagen IV and laminin levels associate with type 2 diabetes, glycemic control, major adverse cardiac events, and mortality in coronary bypass patients. Cardiovasc Diabetol. Published 17 December 2025. doi:10.
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