Association between the cumulative estimated glucose disposal rate and incident cardiovascular disease in individuals over the age of 50 years and without diabetes: data from two large cohorts in China and the United States
Authors' conclusion
A lower level of cumulative eGDR was associated with an increased risk of incident CVD in individuals over the age of 50 years and without diabetes. Continuous monitoring of cumulative eGDR exposure over time, based on consideration of traditional risk factors, may prove beneficial for the early identification and intervention of individuals at high risk of CVD. In regions with limited healthcare resources, among individuals with limited ability to access, process, and understand health information and services, cumulative eGDR may offer improved clinical applicability.
Study context
- Population
- Individuals over the age of 50 years without diabetes; China Health and Retirement Longitudinal Study (CHARLS) median age 59 years (IQR 55–65), 49.59% men; Health and Retirement Study (HRS) median age 64 years (IQR 57–70), 35.11% men
- Participants
- 2,430 vs 2,008
- Exposure
- Cumulative estimated glucose disposal rate (eGDR) and incident cardiovascular disease (CVD)
- CHARLSn = 2,430
- HRSn = 2,008
- Outcome
- Incident CVD
Methodological detailstwo cohorts (CHARLS and HRS), Cox proportional hazards and restricted cubic spline regression, multivariate adjustment
- Two cohorts (CHARLS and HRS)
- Cox proportional hazards and restricted cubic spline regression
- Multivariate adjustment
Main finding
As reported in the abstract
CHARLS: HR per SD
0.802
95% CI 0.716–0.898
HRS: HR per SD
0.791
95% CI 0.665–0.940
Pooled analysis: HR per SD
0.799
95% CI 0.726–0.878
Observational data: associations, not effects.
Further findings
Shape of association (restricted cubic spline (RCS)): negative and linear
- CHARLS: P < 0.001, P for nonlinearity = 0.248
- HRS: P = 0.013, P for nonlinearity = 0.121
Original publication
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