Association between C-reactive protein-triglyceride-glucose index and risk of stroke in different renal function status: a national cohort study
Main finding · Incident stroke per 1-unit increase in CTIResult — go to the resultHazard ratio 1.15 95% CI 1.00–1.32Authors' conclusion
Elevated CTI levels are associated with an increased risk of stroke in middle-aged and older Chinese adults, particularly among individuals with mild renal impairment. By combining inflammatory and metabolic markers, CTI might offer potential clinical value for risk assessment.
Study context
- Population
- Adults aged ≥45 years, China Health and Retirement Longitudinal Study (CHARLS), 2011–2018; mean age 59.48 (9.41) years, 46.5% male
- Participants
- 8,808 adults
- Exposure
- Higher vs lower C-reactive protein-triglyceride-glucose index
- Outcome
- Incident stroke
- Follow-up
- Median 7 years
Methodological detailsnational cohort, stratified by estimated glomerular filtration rate (eGFR) with interaction terms
- National cohort
- Stratified by eGFR with interaction terms
Main finding
Incident stroke per 1-unit increase in CTI
Hazard ratio
1.15
95% CI 1.00–1.32
CTI per 1-unit increase
HR 1.15 (95% CI 1.00–1.32)
Per 1-unit increase, as printed
As reported in the abstract
- Stroke events
- 404 (4.6%)
- Positive linear dose-response relationship
- P overall <0.001, P non-linear= 0.289
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Stroke, mildly reduced renal function (eGFR 60-89 mL/min/1.73 m²)CTI Q4vs CTI Q1 | 2.73 (1.16–6.40) | |
| 0.10.31310Hazard ratio (log scale) |
Interaction between CTI and eGFR on stroke risk
- Significant interaction between CTI and eGFR levels
- P = 0.037
Stroke, preserved (eGFR ≥ 90) or moderately-to-severely reduced (eGFR < 60) renal function
- No significant associations
Original publication
Association between C-reactive protein-triglyceride-glucose index and risk of stroke in different renal function status: a national cohort study. Cardiovasc Diabetol. Published 14 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →