Association Between Atrial Fibrillation and Diabetes-Related Complications: A Nationwide Cohort Study
Authors' conclusion
Among patients with diabetes, concurrent atrial fibrillation was associated with increased risks for diabetes-related macrovascular complications, diabetic nephropathy, and diabetic foot. Such patients require holistic management to reduce the risk of adverse outcomes.
Study context
- Population
- Patients with diabetes who underwent health checkups 2009–2012, Korean National Health Insurance Service databasematched cohort
- Participants
- 65,760 patients
- Exposure
- AF vs no AF
- AFn = 10,960
- No AFn = 54,800reference
- Outcome
- Diabetes-related complications
Methodological detailsobservational, propensity-score matched 1:5
- Observational
- Propensity-score matched 1:5
Main finding
As reported in the abstract
AF vs No AFHazard ratio (95% CI)
Macrovascular complications
1.12(1.09–1.16)
Diabetic nephropathy
1.23(1.16–1.30)
Diabetic foot complications
1.13(1.09–1.17)
Diabetic retinopathy; risk comparable
0.99(0.96–1.03)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Diabetic foot amputation | 4.12 (1.98–8.56) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Association Between Atrial Fibrillation and Diabetes-Related Complications: A Nationwide Cohort Study. Diabetes Care. Published 18 October 2023. doi:10.
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