Association of age at diagnosis of type 2 diabetes mellitus with the risks of the morbidity of cardiovascular disease, cancer and all-cause mortality: Evidence from a real-world study with a large population-based cohort study
Authors' conclusion
Th earlier the diagnosis of T2DM, the higher the risk for subsequent adverse outcomes. It is imperative to enhance the management and monitoring of early-onset patients during follow-up.
Study context
- Population
- T2D patients from Ningbo and Jinhua city, Zhejiang province, China
- Participants
- 549,959 patients
- Exposure
- T2D diagnosis age groups, youngest vs oldest
- Outcome
- Risks of CHD, stroke, cancer and all-cause death by T2D diagnosis age group (standardized ratios)
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Excess risks of adverse outcomes by diagnosis age
| Group | Standardized incidence ratios (SIR) coronary heart disease (CHD) | SIR stroke | SIR cancer | Standardized mortality ratios (SMR) all-cause death |
|---|---|---|---|---|
| 30-39 | 5.93 (95% CI: 3.46, 10.14) | 5.45 (95% CI: 3.72, 7.99) | 1.85 (95% CI: 1.38, 2.49) | 3.15 (1.69, 5.84) |
| ≥80 | 1.32 (95% CI: 1.08, 1.60) | 1.25 (95% CI: 1.08, 1.44) | 0.78 (95% CI: 0.56, 1.09) | 1.12 (0.88, 1.43) |
Standardized incidence ratios (SIR) coronary heart disease (CHD)
30-395.93 (95% CI: 3.46, 10.14)
≥801.32 (95% CI: 1.08, 1.60)
SIR stroke
30-395.45 (95% CI: 3.72, 7.99)
≥801.25 (95% CI: 1.08, 1.44)
SIR cancer
30-391.85 (95% CI: 1.38, 2.49)
≥800.78 (95% CI: 0.56, 1.09)
Standardized mortality ratios (SMR) all-cause death
30-393.15 (1.69, 5.84)
≥801.12 (0.88, 1.43)
- Excess risks decreased with increasing diagnosis age
- all P value < 0.001
Observational data: associations, not effects.
Further findings
Sensitivity analyses: stratified by sex; excluding time from diagnosis to endpoint <1 or 2 years
- Consistent results
Original publication
Association of age at diagnosis of type 2 diabetes mellitus with the risks of the morbidity of cardiovascular disease, cancer and all-cause mortality: Evidence from a real-world study with a large population-based cohort study. Diabetes Res Clin Pract. Published 26 September 2024. doi:10.
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