Association of 25-hydroxyvitamin D, lipoprotein-associated phospholipase A2 and asymptomatic coronary artery disease in patients with type 2 diabetes mellitus
Authors' conclusion
Decreased 25(OH)D and increased Lp-PLA2 could identify patients with a high risk of CAD and are associated with the severity of coronary artery stenosis in T2DM.
Study context
- Population
- Patients with T2D with no history or symptoms of CVD; all underwent coronary CT angiography66 matched pairs
- Participants
- 66 vs 66
- Comparison
- T2D patients with coronary artery disease (CAD) vs without CAD
- CADn = 66
- Without CADn = 66reference
- Outcome
- Association of 25(OH)D and Lp-PLA2 with CAD
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
25(OH)D associated with decreased risk of CAD, aOR (95% CI 0.887-0.983), P = 0.009
0.933
Lp-PLA2 associated with increased risk of CAD, aOR (95% CI 1.005-1.022), P = 0.002
1.014
Observational data: associations, not effects.
Further findings
Vitamin D sufficiency
- Vitamin D sufficiency group had lower prevalence of CAD and lower Lp-PLA2 levels
Correlations of 25(OH)D
- 25(OH)D inversely correlated with Lp-PLA2, Gensini score, Leiden score, segment involvement score and segment stenosis score
- P < 0.05
Original publication
Association of 25-hydroxyvitamin D, lipoprotein-associated phospholipase A2 and asymptomatic coronary artery disease in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 25 April 2024. doi:10.
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